• Improvement of physical exercise capacity in patients with Coronary Artery Disease NYHA 2-3
  • Chronic Heart Failure (in research)
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Physiological effects:
  • Improves the microcirculation [Belyavskiy et al., Bobyleva et al., Ischuk et al., Townsend et al.]
  • Reduces endothelial dysfunction [Chiu et al. , Elchaninova et al., Haider et al., Manukhina et al.]
  • Decreases the blood pressure [Ainslie et al. , Bailey et al. , Elchaninova et al., Lyamina et al. , Manukhina et al., Shatilo et al.]
  • Increases myocardium and brain resistance to acute ischaemia (precondition-like effect) [Bulgak et al., Zhua et al.]
  • Reduction in the negative consequences of systemic oxidative stress [Arkhipenko et al., Borukaeva et al., Elchaninova et al.]
Clinical Effects:
  • Increases time to fatigue
  • Increases physical endurance
  • Increases VO2 peak
  • Increases %VO2 max
  • Increases Anaerobic threshold
  • Lowers incidence of angina as a reason to stop treadmill run
  • Lowers incidence of ST depression as a reason to stop treadmill run
Lang. Title Year Authors Journal PMID
Eng Intermittent Systemic Hypoxic-Hyperoxic Training for Myocardial Protection in Patients Undergoing Coronary Artery Bypass Surgery: First Results From a Single-Centre, Randomised Controlled Trial 2018 Tuter DS, Kopylov P, Syrkin A, Glazachev O, Komarov R, Katkov A, Severova L, Ivanova E, Zhang Y, Saner H Open Heart 30487981
Eng Intermittent Hypoxia–Hyperoxia Conditioning Improves Cardiorespiratory Fitness in Older Comorbid Cardiac Outpatients Without Hematological Changes: A Randomized Controlled Trial 2018 Dudnik E, Zagaynaya E, Glazachev O, Susta D HIGH ALTITUDE MEDICINE & BIOLOGY 30251879
Eng Adaptations following an intermittent hypoxia-hyperoxia training in coronary artery disease patients: a controlled study 2017 Glazachev O, Kopylov P, Susta D, Dudnik E, Zagaynaya E Clinical Cardiology 28323322
Eng A programme based on repeated hypoxia–hyperoxia exposure and light exercise enhances performance in athletes with overtraining syndrome: a pilot study 2015 Susta D, Glazachev O, Dudnik E Clin Physiol Funct Imaging 26443707
Eng Intermittent hypoxic–hyperoxic training on cognitive performance in geriatric patients 2017 Bayer U, Likar R, Pinter G, Stettner H, Demschar S, Trummer B, Neuwersch S, Glazachev O, Burtscher M Alzheimer’s & Dementia: Translational Research & Clinical Interventions 29067323
Eng Effects of intermittent hypoxia-hyperoxia on mobility and perceived health in geriatric patients performing a multimodal training intervention: a randomized controlled trial 2019 Bayer U, Likar R, Pinter G, Stettner H, Demschar S, Trummer B, Neuwersch S, Glazachev O, Burtscher M BMC Geriatrics 31200649
Eng Hypoxic training: Clinical benefits on cardiometabolic risk factors 2014 Wee J, Climstein M J Sci Med Sport. 24268571
Eng Effect of hypoxic training on inflammatory and metabolic risk factors: a crossover study in healthy subjects. 2014 Shi B, Watanabe T, Shin S, Yabumoto T, Takemura M, Matsuoka T Physiol Rep. 24744877
Eng Trends in the use of preconditioning to hypoxia for early prevention of future life diseases 2013 Basovich SN Biosci Trends 23524890